The New Species Brucella microti Replicates in Macrophages and Causes Death in Murine Models of Infection
Identifieur interne : 000449 ( Main/Exploration ); précédent : 000448; suivant : 000450The New Species Brucella microti Replicates in Macrophages and Causes Death in Murine Models of Infection
Auteurs : María P. Jiménez De Bagüés [Espagne] ; Safia Ouahrani-Bettache [France] ; Juan F. Quintana [Espagne] ; Olga Mitjana [Espagne] ; Nabil Hanna [France] ; Stéphanie Bessoles [France] ; Françoise Sanchez [France] ; Holger C. Scholz [Allemagne] ; Virginie Lafont [France] ; Stephan Köhler [France] ; Alessandra Occhialini [France]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2010-07-01.
Abstract
Background. The recent isolation of Brucella microti from the common vole, the red fox, and the soil raises the possibility of an eventual reemergence of brucellosis in Europe. In this work, the pathogenic potential of this new Brucella species in both in vitro and in vivo models of infection was analyzed. Methods. The ability of B. microti (as compared to that of the closely related species Brucella suis) to replicate in human macrophages and in human and murine macrophage-like cells was determined. The behavior of B. microti and B. suis was evaluated in vivo in murine models of infection with Balb/c, CD1, and C57BL/6 mice. Results. B. microti showed an enhanced capacity for intramacrophagic replication compared with that of B. suis. Surprisingly, and in contrast to other species of Brucella, 105 colony-forming units of B. microti killed 82% of Balb/c mice within 7 days. Infection of spleen and liver with B. microti peaked at day 3, compared with B. suis infection, which peaked at day 7. Sublethal doses of B. microti induced good protection against a subsequent challenge with lethal doses. Conclusions. In experimental cellular and murine infections, B. microti exhibited a high pathogenic potential, compared with other Brucella species.
Url:
DOI: 10.1086/653084
Affiliations:
- Allemagne, Espagne, France
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
- Université Montpellier 1, Université Montpellier 2
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Curation: 001572
- to stream Istex, to step Checkpoint: 000199
- to stream Main, to step Merge: 000449
- to stream Main, to step Curation: 000449
Le document en format XML
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Scholz</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Bacteriology, Bundeswehr Institute of Microbiology</wicri:regionArea><wicri:noRegion>Bundeswehr Institute of Microbiology</wicri:noRegion><wicri:noRegion>Bundeswehr Institute of Microbiology</wicri:noRegion></affiliation></author><author><name sortKey="Lafont, Virginie" sort="Lafont, Virginie" uniqKey="Lafont V" first="Virginie" last="Lafont">Virginie Lafont</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, Unité Mixte de Recherche (UMR) 5236, Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="4"><country 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xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, Unité Mixte de Recherche (UMR) 5236, Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>UMR 5236, CPBS, Université Montpellier I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Montpellier II, 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xml:lang="fr">France</country><wicri:regionArea>UMR 5236, CPBS, Université Montpellier I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Montpellier II, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 2</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University Chicago Press</publisher><date type="published" when="2010-07-01">2010-07-01</date><biblScope unit="volume">202</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="3">3</biblScope><biblScope unit="page" to="10">10</biblScope></imprint><idno type="ISSN">0022-1899</idno></series><idno type="istex">8799C525C2DF2F14574A7157E7EB70FB20F7AE8D</idno><idno type="DOI">10.1086/653084</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background. The recent isolation of Brucella microti from the common vole, the red fox, and the soil raises the possibility of an eventual reemergence of brucellosis in Europe. In this work, the pathogenic potential of this new Brucella species in both in vitro and in vivo models of infection was analyzed. Methods. The ability of B. microti (as compared to that of the closely related species Brucella suis) to replicate in human macrophages and in human and murine macrophage-like cells was determined. The behavior of B. microti and B. suis was evaluated in vivo in murine models of infection with Balb/c, CD1, and C57BL/6 mice. Results. B. microti showed an enhanced capacity for intramacrophagic replication compared with that of B. suis. Surprisingly, and in contrast to other species of Brucella, 105 colony-forming units of B. microti killed 82% of Balb/c mice within 7 days. Infection of spleen and liver with B. microti peaked at day 3, compared with B. suis infection, which peaked at day 7. Sublethal doses of B. microti induced good protection against a subsequent challenge with lethal doses. Conclusions. In experimental cellular and murine infections, B. microti exhibited a high pathogenic potential, compared with other Brucella species.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement><orgName><li>Université Montpellier 1</li><li>Université Montpellier 2</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Jimenez De Bagues, Maria P" sort="Jimenez De Bagues, Maria P" uniqKey="Jimenez De Bagues M" first="María P." last="Jiménez De Bagüés">María P. 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Quintana</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ouahrani Bettache, Safia" sort="Ouahrani Bettache, Safia" uniqKey="Ouahrani Bettache S" first="Safia" last="Ouahrani-Bettache">Safia Ouahrani-Bettache</name></region><name sortKey="Bessoles, Stephanie" sort="Bessoles, Stephanie" uniqKey="Bessoles S" first="Stéphanie" last="Bessoles">Stéphanie Bessoles</name><name sortKey="Bessoles, Stephanie" sort="Bessoles, Stephanie" uniqKey="Bessoles S" first="Stéphanie" last="Bessoles">Stéphanie Bessoles</name><name sortKey="Bessoles, Stephanie" sort="Bessoles, Stephanie" uniqKey="Bessoles S" first="Stéphanie" last="Bessoles">Stéphanie Bessoles</name><name sortKey="Hanna, Nabil" sort="Hanna, Nabil" uniqKey="Hanna N" first="Nabil" last="Hanna">Nabil Hanna</name><name sortKey="Hanna, Nabil" sort="Hanna, Nabil" uniqKey="Hanna N" first="Nabil" last="Hanna">Nabil Hanna</name><name sortKey="Hanna, Nabil" sort="Hanna, Nabil" uniqKey="Hanna N" first="Nabil" last="Hanna">Nabil Hanna</name><name sortKey="Kohler, Stephan" sort="Kohler, Stephan" uniqKey="Kohler S" first="Stephan" last="Köhler">Stephan Köhler</name><name sortKey="Kohler, Stephan" sort="Kohler, Stephan" uniqKey="Kohler S" first="Stephan" last="Köhler">Stephan Köhler</name><name sortKey="Kohler, Stephan" sort="Kohler, Stephan" uniqKey="Kohler S" first="Stephan" last="Köhler">Stephan Köhler</name><name sortKey="Lafont, Virginie" sort="Lafont, Virginie" uniqKey="Lafont V" first="Virginie" last="Lafont">Virginie Lafont</name><name sortKey="Lafont, Virginie" sort="Lafont, Virginie" uniqKey="Lafont V" first="Virginie" last="Lafont">Virginie Lafont</name><name sortKey="Lafont, Virginie" sort="Lafont, Virginie" uniqKey="Lafont V" first="Virginie" last="Lafont">Virginie Lafont</name><name sortKey="Occhialini, Alessandra" sort="Occhialini, Alessandra" uniqKey="Occhialini A" first="Alessandra" last="Occhialini">Alessandra Occhialini</name><name sortKey="Occhialini, Alessandra" sort="Occhialini, Alessandra" uniqKey="Occhialini A" first="Alessandra" last="Occhialini">Alessandra Occhialini</name><name sortKey="Occhialini, Alessandra" sort="Occhialini, Alessandra" uniqKey="Occhialini A" first="Alessandra" last="Occhialini">Alessandra Occhialini</name><name sortKey="Occhialini, Alessandra" sort="Occhialini, Alessandra" uniqKey="Occhialini A" first="Alessandra" last="Occhialini">Alessandra Occhialini</name><name sortKey="Ouahrani Bettache, Safia" sort="Ouahrani Bettache, Safia" uniqKey="Ouahrani Bettache S" first="Safia" last="Ouahrani-Bettache">Safia Ouahrani-Bettache</name><name sortKey="Ouahrani Bettache, Safia" sort="Ouahrani Bettache, Safia" uniqKey="Ouahrani Bettache S" first="Safia" last="Ouahrani-Bettache">Safia Ouahrani-Bettache</name><name sortKey="Sanchez, Francoise" sort="Sanchez, Francoise" uniqKey="Sanchez F" first="Françoise" last="Sanchez">Françoise Sanchez</name><name sortKey="Sanchez, Francoise" sort="Sanchez, Francoise" uniqKey="Sanchez F" first="Françoise" last="Sanchez">Françoise Sanchez</name><name sortKey="Sanchez, Francoise" sort="Sanchez, Francoise" uniqKey="Sanchez F" first="Françoise" last="Sanchez">Françoise Sanchez</name></country><country name="Allemagne"><noRegion><name sortKey="Scholz, Holger C" sort="Scholz, Holger C" uniqKey="Scholz H" first="Holger C." last="Scholz">Holger C. 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